Treatment review · GLP-1 · 2026
Semaglutide
GLP-1 receptor agonist used for weight management and glycemic control.
- Expert score
- 9.1/10
- Community interest (editorial)
- 8.7/10
- Cost per month
- $179–$1400
- Providers offering it
- 25in our directory
Both scores are PeakedLabs editorial assessments — community interest reflects our read of discussion volume and demand, not user ratings.
How it works
“Think of it as turning down hunger signals so eating less feels easier.”
Mechanism of action
Increases satiety, slows gastric emptying, and improves glucose-dependent insulin response.
Typical dosing
0.25 mg weekly titrated up to 1-2.4 mg weekly.
Protocols vary by clinic and individual labs. Dose with a licensed clinician, not a forum thread.
Common use cases
- 01weight loss
- 02insulin resistance
- 03appetite control
Side effects
- nausea
- constipation
- reflux
Legal & regulatory status
- FDA status
- FDA-approved active ingredient
Prescription only; branded and compounded pathways vary by regulation.
Where to get it
Providers below currently advertise relevant glp-1 programs, ranked by PeakedLabs score.
| Provider | Score | Price | Actions |
|---|---|---|---|
| Marek Health | 9.1 | $180–$650/mo | Visit |
| Defy Medical | 8.9 | $165–$625/mo | Visit |
| Superpower | 8.9 | $349/year | Visit |
| Maximus | 8.8 | $149–$349/mo | Visit |
| Transcend | 8.5 | $179–$599/mo | Visit |
| Hims | 8.4 | $39–$399/mo | Visit |
| Amazing Meds | 8.4 | $185–$620/mo | Visit |
| TRT Nation | 8.3 | $125–$325/mo | Visit |
| Peter MD | 8.2 | $129–$399/mo | Visit |
| HydraMed | 8.2 | $150–$459/mo | Visit |
| AlynMD | 8.1 | $165–$495/mo | Visit |
| Ro (Roman) | 8.1 | $30–$450/mo | Visit |
| Elite HRT | 8.1 | $155–$445/mo | Visit |
| Viking Alternative | 8.0 | $130–$360/mo | Visit |
| Evolve Telemed | 8.0 | $159–$430/mo | Visit |
| GameDay Men's Health | 8.0 | $199–$525/mo (est.) | Visit |
| Aspire Rejuvenation | 8.0 | $165–$499/mo | Visit |
| Inception Telehealth | 8.0 | $159–$475/mo | Visit |
| Blokes | 7.9 | $129–$379/mo | Visit |
| Frontline Alternative | 7.8 | $145–$425/mo | Visit |
| Optimal Health | 7.7 | $150–$430/mo | Visit |
| Matrix Hormones | 7.7 | $149–$430/mo | Visit |
| Henry Meds | 7.6 | $249–$449/mo | Visit |
| Shed | 7.4 | $199–$399/mo | Visit |
| Low T Center | 7.3 | $180–$425/mo | Visit |
Provider-tracked monthly range: $30–$650
Disclosure: PeakedLabs may earn a commission from partner links. Editorial scoring and rankings remain independent.
Experts covering this treatment
Expert directoryThomas DeLauer
Metabolic health and nutrition protocol educator
Dr. Berg
Keto and metabolic education creator
Peter Attia
Longevity medicine physician and educator
Layne Norton
Evidence-based nutrition and training educator
Mark Sisson
Primal health and metabolic flexibility author
Danny Matranga
Online fitness coach focused on sustainable fat loss
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Frequently asked questions
What is Semaglutide usually used for?
Semaglutide is typically discussed for weight loss, insulin resistance, appetite control. 25 tracked providers currently list options in this category.
How is Semaglutide commonly dosed?
Common protocols reported by clinics and patients: 0.25 mg weekly titrated up to 1-2.4 mg weekly. Always individualize with a licensed clinician.
Is Semaglutide legal in the U.S.?
Prescription only; branded and compounded pathways vary by regulation.
What side effects should I watch for with Semaglutide?
Commonly reported effects include nausea, constipation, reflux. Escalate any severe or persistent symptoms to your care team quickly.
Treatment Planning
Match Treatment Choice to Provider Execution
Choose providers with reliable monitoring and refill workflows for this treatment category.
Disclosure: PeakedLabs may earn a commission from partner links. Editorial scoring and rankings remain independent.