Treatment review · Longevity · 2026
Metformin
Insulin-sensitizing medication commonly used for glycemic control and longevity-focused protocols.
- Editorial score
- 8.0/10
- Community interest (editorial)
- 7.7/10
- Estimated cost per month
- $8–$40
- Providers with related programs
- 17in our directory
Both scores are PeakedLabs editorial assessments — community interest reflects our read of discussion volume and demand, not user ratings. Cost ranges are editorial estimates, not quotes or purchasable offers. A related program does not confirm that a clinic offers this specific treatment or that it is appropriate for you.
How it works
“Think of it as supporting long-term cell energy and recovery systems that decline with age.”
Mechanism of action
Activates AMPK and reduces hepatic glucose output.
Typical dosing
500-2,000 mg daily, usually titrated gradually.
Protocols vary by clinic and individual labs. Dose with a licensed clinician, not a forum thread.
Common use cases
- 01insulin resistance
- 02weight management
- 03longevity
Side effects
- GI upset
- vitamin B12 depletion
- fatigue
Legal & regulatory status
- FDA status
- FDA-approved
Prescription only.
Provider research
Providers below advertise related longevity programs, ranked by PeakedLabs editorial score. Confirm the specific treatment, current availability and full price directly.
| Provider | Score | Price | Actions |
|---|---|---|---|
| Marek Health | 9.1 | $180–$650/mo | Visit |
| Defy Medical | 8.9 | $165–$625/mo | Visit |
| Superpower | 8.9 | $199/year | Visit |
| Maximus | 8.8 | $149–$349/mo | Visit |
| Transcend | 8.5 | $179–$599/mo | Visit |
| Hims | 8.4 | All-in monthly total not verified | Visit |
| Amazing Meds | 8.4 | $185–$620/mo | Visit |
| HydraMed | 8.2 | $150–$459/mo | Visit |
| AlynMD | 8.1 | $165–$495/mo | Visit |
| Ro (Roman) | 8.1 | $30–$450/mo | Visit |
| Evolve Telemed | 8.0 | $159–$430/mo | Visit |
| Aspire Rejuvenation | 8.0 | $165–$499/mo | Visit |
| Inception Telehealth | 8.0 | $159–$475/mo | Visit |
| Blokes | 7.9 | $129–$379/mo | Visit |
| Prime Body | 7.8 | $149–$435/mo | Visit |
| Henry Meds | 7.6 | $249–$449/mo | Visit |
| Shed | 7.4 | $199–$399/mo | Visit |
Related-program monthly range (may include estimates, not a treatment quote): $30–$650
Disclosure: PeakedLabs may earn a commission from partner links. Editorial scoring and rankings remain independent.
Experts covering this treatment
Expert directoryAndrew Huberman
Neuroscience-based performance and recovery educator
Thomas DeLauer
Metabolic health and nutrition protocol educator
Rhonda Patrick
Micronutrient and longevity science communicator
Dr. Berg
Keto and metabolic education creator
Peter Attia
Longevity medicine physician and educator
Bryan Johnson
Data-heavy longevity experimenter
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Related treatments
Frequently asked questions
What is Metformin usually used for?
Metformin is typically discussed for insulin resistance, weight management, longevity. 17 tracked providers currently list options in this category.
How is Metformin commonly dosed?
Common protocols reported by clinics and patients: 500-2,000 mg daily, usually titrated gradually. Always individualize with a licensed clinician.
Is Metformin legal in the U.S.?
Prescription only.
What side effects should I watch for with Metformin?
Commonly reported effects include GI upset, vitamin B12 depletion, fatigue. Escalate any severe or persistent symptoms to your care team quickly.
Treatment Planning
Match Treatment Choice to Provider Execution
Choose providers with reliable monitoring and refill workflows for this treatment category.
Disclosure: PeakedLabs may earn a commission from partner links. Editorial scoring and rankings remain independent.