Treatment Review 2026
Metformin
Insulin-sensitizing medication commonly used for glycemic control and longevity-focused protocols.
$8 - $40
Per month
Think of it as supporting long-term cell energy and recovery systems that decline with age.
Detailed
Activates AMPK and reduces hepatic glucose output.
500-2,000 mg daily, usually titrated gradually.
Use Cases
- GI upset
- vitamin B12 depletion
- fatigue
Prescription only.
Providers below currently advertise relevant longevity programs.
Provider-tracked monthly range: $30 - $699
Andrew Huberman
Neuroscience-based performance and recovery educator
Thomas DeLauer
Metabolic health and nutrition protocol educator
Rhonda Patrick
Micronutrient and longevity science communicator
Dr. Berg
Keto and metabolic education creator
Peter Attia
Longevity medicine physician and educator
Bryan Johnson
Data-heavy longevity experimenter
What is Metformin usually used for?
Metformin is typically discussed for insulin resistance, weight management, longevity. 18 tracked providers currently list options in this category.
How is Metformin commonly dosed?
Common protocols reported by clinics and patients: 500-2,000 mg daily, usually titrated gradually. Always individualize with a licensed clinician.
Is Metformin legal in the U.S.?
Prescription only.
What side effects should I watch for with Metformin?
Commonly reported effects include GI upset, vitamin B12 depletion, fatigue. Escalate any severe or persistent symptoms to your care team quickly.