Treatment review · Longevity · 2026
Rapamycin (Sirolimus)
mTOR inhibitor explored off-label in longevity circles.
- Expert score
- 8.1/10
- Community interest (editorial)
- 7.2/10
- Cost per month
- $25–$180
- Providers offering it
- 17in our directory
Both scores are PeakedLabs editorial assessments — community interest reflects our read of discussion volume and demand, not user ratings.
How it works
“Think of it as supporting long-term cell energy and recovery systems that decline with age.”
Mechanism of action
Inhibits mTOR signaling tied to growth and aging pathways.
Typical dosing
1-10 mg weekly in physician-supervised off-label protocols.
Protocols vary by clinic and individual labs. Dose with a licensed clinician, not a forum thread.
Common use cases
- 01longevity
- 02inflammation modulation
- 03metabolic health
Side effects
- mouth ulcers
- lipid elevation
- immunosuppression risk
Legal & regulatory status
- FDA status
- FDA-approved for transplant use
Prescription only; longevity use is off-label.
Where to get it
Providers below currently advertise relevant longevity programs, ranked by PeakedLabs score.
| Provider | Score | Price | Actions |
|---|---|---|---|
| Marek Health | 9.1 | $180–$650/mo | Visit |
| Defy Medical | 8.9 | $165–$625/mo | Visit |
| Superpower | 8.9 | $349/year | Visit |
| Maximus | 8.8 | $149–$349/mo | Visit |
| Transcend | 8.5 | $179–$599/mo | Visit |
| Hims | 8.4 | $39–$399/mo | Visit |
| Amazing Meds | 8.4 | $185–$620/mo | Visit |
| HydraMed | 8.2 | $150–$459/mo | Visit |
| AlynMD | 8.1 | $165–$495/mo | Visit |
| Ro (Roman) | 8.1 | $30–$450/mo | Visit |
| Evolve Telemed | 8.0 | $159–$430/mo | Visit |
| Aspire Rejuvenation | 8.0 | $165–$499/mo | Visit |
| Inception Telehealth | 8.0 | $159–$475/mo | Visit |
| Blokes | 7.9 | $129–$379/mo | Visit |
| Prime Body | 7.8 | $149–$435/mo | Visit |
| Henry Meds | 7.6 | $249–$449/mo | Visit |
| Shed | 7.4 | $199–$399/mo | Visit |
Provider-tracked monthly range: $30–$650
Disclosure: PeakedLabs may earn a commission from partner links. Editorial scoring and rankings remain independent.
Experts covering this treatment
Expert directoryBen Greenfield
Longevity and performance biohacking host
Rhonda Patrick
Micronutrient and longevity science communicator
Peter Attia
Longevity medicine physician and educator
Bryan Johnson
Data-heavy longevity experimenter
Siim Land
Longevity and fasting educator
Dr. Dom D Agostino
Ketogenic metabolism and performance researcher
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Frequently asked questions
What is Rapamycin (Sirolimus) usually used for?
Rapamycin (Sirolimus) is typically discussed for longevity, inflammation modulation, metabolic health. 17 tracked providers currently list options in this category.
How is Rapamycin (Sirolimus) commonly dosed?
Common protocols reported by clinics and patients: 1-10 mg weekly in physician-supervised off-label protocols. Always individualize with a licensed clinician.
Is Rapamycin (Sirolimus) legal in the U.S.?
Prescription only; longevity use is off-label.
What side effects should I watch for with Rapamycin (Sirolimus)?
Commonly reported effects include mouth ulcers, lipid elevation, immunosuppression risk. Escalate any severe or persistent symptoms to your care team quickly.
Treatment Planning
Match Treatment Choice to Provider Execution
Choose providers with reliable monitoring and refill workflows for this treatment category.
Disclosure: PeakedLabs may earn a commission from partner links. Editorial scoring and rankings remain independent.