Treatment Review 2026
Rapamycin (Sirolimus)
mTOR inhibitor explored off-label in longevity circles.
$25 - $180
Per month
Think of it as supporting long-term cell energy and recovery systems that decline with age.
Detailed
Inhibits mTOR signaling tied to growth and aging pathways.
1-10 mg weekly in physician-supervised off-label protocols.
Use Cases
- mouth ulcers
- lipid elevation
- immunosuppression risk
Prescription only; longevity use is off-label.
Providers below currently advertise relevant longevity programs.
Provider-tracked monthly range: $30 - $699
Ben Greenfield
Longevity and performance biohacking host
Rhonda Patrick
Micronutrient and longevity science communicator
Peter Attia
Longevity medicine physician and educator
Bryan Johnson
Data-heavy longevity experimenter
Siim Land
Longevity and fasting educator
Dr. Dom D Agostino
Ketogenic metabolism and performance researcher
What is Rapamycin (Sirolimus) usually used for?
Rapamycin (Sirolimus) is typically discussed for longevity, inflammation modulation, metabolic health. 18 tracked providers currently list options in this category.
How is Rapamycin (Sirolimus) commonly dosed?
Common protocols reported by clinics and patients: 1-10 mg weekly in physician-supervised off-label protocols. Always individualize with a licensed clinician.
Is Rapamycin (Sirolimus) legal in the U.S.?
Prescription only; longevity use is off-label.
What side effects should I watch for with Rapamycin (Sirolimus)?
Commonly reported effects include mouth ulcers, lipid elevation, immunosuppression risk. Escalate any severe or persistent symptoms to your care team quickly.